NON-SMALL CELL LUNG CANCER (NSCLC), EGFR DOWNSTREAM PATHWAY ACTIVATION AND TKI TARGETED THERAPIES SENSITIVITY: EFFECT OF THE PLASMA MEMBRANE-ASSOCIATED NEU3.

Adenocarcinoma of Non-Small Cell Lung Cancer (NSCLC) is a severe disease.Patients carrying EGFR mutations may benefit from EGFR targeted therapies (e.g.: gefitinib).Recently, it has been shown that sialidase NEU3 directly interacts and regulates EGFR.In this work, we investigate the effect of sialidase NEU3 overexpression on EGFR pathways activatio

The relentless growth of multidrug resistance and generation of recalcitrant biofilm are major obstacles in treating wounds, particularly in austere military environments where broad-spectrum pathogen coverage is needed.Designed antimicrobial peptides (dAMPs) are constructed analogs of naturally occurring AMPs that provide the first line of defense

Romania has the Sneakers for Men - Grey - Canvas Mesh Athletic Running Shoes largest number of EU holdings.For this purpose, this paper analyses the effect of the excessive agricultural land fragmentation caused by the laws and measures adopted in the previous period.The existence of small holdings is influenced by the land property structures and

Given significant genetic, molecular, and phenotypic overlaps, researchers have begun to investigate whether targeted treatments for Fragile X Syndrome (FXS) could also be beneficial for patients with Autism Spectrum Disorder (ASD).For example, low-dose sertraline, an SSRI, was used in two recent controlled trials in children with FXS and ASD.The f